taught by Nancy A. Moran, Regents' Professor in Ecology and Evolutionary Biology
held Wednesdays 2:00-3:50, BioSciences West rm. 302
This course aims to link the basics of molecular biology to the new findings in genomics. Most students in the class are interested in medical aspects of genomics as well as evolution of genomes, so these aspects will be emphasized.
A USEFUL SITE FOR SIMPLE EXPLANATIONS OF MOLECULAR BIOLOGY TERMS: http://www.genome.gov/DIR/VIP/Learning_Tools/
(subject to change - last updated 2/2/2007)
Readings labeled "DNA" are from the course text by JD Watson & A Berry.
Other readings will be distributed or downloaded from the UA library—NM
| Date | Topic | Readings | handouts | Students Presenting* |
|---|---|---|---|---|
| 10-Jan | Introduction, Topics & Schedule | na | ||
| 17-Jan | Reviewing Molecular Biology Basics | DNA: introd, Ch1, Ch2 (through p. 61) | Mol Biol Review quiz, MolBiology Review sheets | na |
| 24-Jan | More Reviewing Molecular BIology Basics |
DNA: Ch3, Ch4, Ch 5 (pp 62-133) |
GenBank exercise, Presentation Info | |
| 31-Jan | Sequencing Methods and the Human Genome. Guest: Prof. Howard Ochman (EEB & Biochemistry) |
DNA: Ch7 (pp 164-193) | Brittany, Kristen, Jon, Sarah | |
| 7-Feb | Evolution of DNA sequences | DNA: Ch8 (pp 195-227) | Bobby, Jenny, Jorj, Amy | |
| 14-Feb | Reading genomes, transcriptomes |
Answer questions handed out on Ch8 | questions on Ch8 | Katie, Adrienne, Bridget |
| 21-Feb | Reconstructing Human Origins using DNA | DNA: Ch9 (pp 229-259) | ||
| 28-Feb | DNA: Ch 10 | complete the Genbank exercise (Pt II) | Jon, Jenny, Jorj, Ian | |
| 5 Mar | written assignment 1 due at 5 pm (1st draft) by email |
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| 7-Mar | Reconstructing Human Origins using DNA - guest speaker Professor Michael Hammer |
Reed, F.A., Tishkoff, S.A. African human diversity, origins, & migrations. Current Opinions in Genetics & Develop. 16: 597-605 |
written assignment 1 comments returned |
Kristen, Brittany, Sarah |
| 14-Mar | Spring Break | |||
| 21-Mar | written assignment 1 due in class as hard copy (final draft + 1st draft) |
Katie, Amy, Adrienne, Bobby, Bridget |
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28 March |
DNA: Ch11-12 |
Ian, Brittany, Kristen | ||
| 4-Apr | The origin and evolution of HIV-guest speaker Professor Michael Worobey | Worobey Reading on HIV | Jenny, Sarah | |
| 11-Apr | Tour of BIO5 building, meet at BIO5 (North of Speedway) at 2:10 pm |
|
written assignment 2 due (1st draft) | (none) |
| 18-Apr | DNA: Ch13 & Coda |
Amy, Bobby, Bridget | ||
| 25-Apr | (articles emailed, or obtain from UA library) Ley et al. 2006 Nature 444: 1022 Ley et al. 2007 Environmental Microbiology 9:3 Turnbaugh et al 2006 Nature 444:1027 Bajzer and Seeley 2006 Nature 444:1009 |
written assignment 2 due in class (final draft+1st draft) | Katie, Ian, Jon, Jorj, Adrienne | |
| 2-May |
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